| 1907-1908 | W. C. Acree, Principal, Third District Agricultural and Mechanical School |
| 1908-1921 | John M. Collum, Principal, Third District Agricultural and Mechanical School |
| 1921-1934 | John Monroe Prance, Georgia Southwestern College |
| 1921-1926 Principal, Third District Agricultural and Mechanical School |
| 1926-1932 President, Agricultural and Normal College |
| 1932-1934 President, Georgia Southwestern College |
| 1934-1948 | Peyton Jacob, President, Georgia Southwestern College |
| 1948-1950 | Henry King Stanford, President, Georgia Southwestern College |
| 1950-1963 | Lloyd A. Moll, President, Georgia Southwestern College |
| 1963-1978 | William B. King, President, Georgia Southwestern College |
| 1978-1979 | Harold T. Johnson, Acting President, Georgia Southwestern College |
| 1979-1995 | William H. Capitan, President, Georgia Southwestern College |
| 1996-1996 | Joan M. Lord, Acting President, Georgia Southwestern College |
| 1996-2007 | Michael L. Hanes, President, Georgia Southwestern State University |
| 2007- | Kendall A. Blanchard, President, Georgia Southwestern State University |